Figure 1.

Representative responses of mean hindlimb vascular conductance in males (top) and females (bottom) to illustrate complete Y₁R blockade using BIBP3226 (100 μg kg⁻¹). NPY (100 μm; 160 μl)-mediated vasoconstriction (Δ=−1.0 ± 0.03 μl min⁻¹ mmHg⁻¹ in males and −0.6 ± 0.03 μl min⁻¹ mmHg⁻¹ in females) was abolished by BIBP3226 (100 μg kg⁻¹). This dose of BIBP3226 blocked any effect of a subsequent 100 μm infusion of NPY (n = 3 males, 3 females).