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. 2004 Nov 18;562(Pt 2):455–475. doi: 10.1113/jphysiol.2004.071068

Figure 4. Effect of potassium-induced depolarization on pHi with bathing solution osmolarity held constant.

Figure 4

A, example of the rise in pHi that occurred in rat myocytes bathed in CO2/HCO3−-buffered solution and exposed to high [K+]o for 10 min. B, summary of results from rat myocytes bathed in CO2/HCO3−-buffered (n = 7) and Hepes-buffered (n = 5) solution. C, mean change in rat pHi following 10 min exposure to high [K+]o (CO2/HCO3− buffer) in the absence (n = 7) and presence of S0859 (n = 4). The NBC inhibitor completely blocked the rise in pHi. D, summary of the rise in pHi elicited by 10 min exposure to high [K+]o in CO2/HCO3−-buffered solution (rat, n = 7; rabbit, n = 13; guinea pig, n = 13). *P < 0.05 (paired).