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. 2004 Nov 18;562(Pt 2):455–475. doi: 10.1113/jphysiol.2004.071068

Table 1.

Estimate of JNBCe/JtotNBC in resting myocytes under normal conditions

INBC (pA pF−1) volume (pl) JNBCe (mm min−1) JtotNBC (mm min−1) JNBCe/JtotNBC
Rat 0.04 18a 0.40 0.68 0.6
(pHi 7.05) 32b 0.22 0.68 0.3
44c 0.16 0.68 0.2
Rabbit 0.04 29d 0.28 0.42 0.7
(pHi 7.00) 31e 0.26 0.42 0.6
38f 0.22 0.42 0.5
Guinea pig 0.02 18a 0.18 0.32 0.6
(pHi 7.07) 46c 0.08 0.32 0.3
28g 0.12 0.32 0.4

It was assumed that electrogenic NBC had a 1 : 2 stoichiometry and JNBCe (mm min−1 l−1) was given as: JNBCe= 2(INBC× Cm)/(F× cell volume), where Cm is membrane capacitance (pF) and F is the Faraday constant. Values for Cm were 149 pF (rat), 175 pF (rabbit) and 155 pF (guinea pig). Values of INBC at −85 mV were taken from Fig. 7C and those for JtotNBC at the same pHi were taken from Fig. 2A. Surface/volume ratios (μm2μm−3) were:

b

0.46 (Page, 1978),

c

0.34 (Page et al. 1971),

e

0.56 (Page, 1978),

g

Fixed volume of 28 pl (Campbell et al. 1987).