Table 1.

Qualitative correlations between effects on rates and on affinities

	Effects
Treatment or mutation	Unidirectional rates	Voltage dependence	Na+ affinity	GABA affinity
Valproate	β increases more than α	Rightward shift (small)	Increased	Decreased
SKF	No change in α and β	No change	Unaltered	Unaltered
K448E	Increased β at constant α	Rightward shift	Increased	Decreased
M345H	Increased β at constant α	Rightward shift	Increased	Decreased
T349H	Decreased β at constant α	Leftward shift	Decreased	Increased