Table 1.
Genotype and allele frequencies of rs12255372 in unrelated female German BRCA1/2 mutation-negative familial breast cancer (BC) patients and healthy, unrelated female control subjects
| Genotype | BC Case Patients N (%) | Control Subjects N (%) | OR [95% C.I.], P value a |
| GG | 297 (50.2) | 408 (55.5) | 1.00 |
| GT | 244 (41.2) | 276 (37.6) | 1.21 [0.97, 1.53], 0.09 |
| TT | 51 (8.6) | 51 (6.9) | 1.37 [0.91, 2.08], 0.13 |
| GT+TT | 295 (49.8) | 327 (44.5) | 1.24 [1.00, 1.54], 0.05 |
| Allele | |||
| G | 0.71 | 0.74 | 1.00 |
| T | 0.29 | 0.26 | 1.19 [1.01, 1.42], 0.04 |
| Cochran-Armitage trend test | Ptrend = 0.04 | ||
aOdds ratios (OR) with 95% confidence intervals (95% C.I.) and respective P values were computed by unconditional logistic regression using the Statistical Analysis System software (SAS version 9.1.; SAS Institute Inc., Cary, NC). Adjustment for age did not change the ORs, assuming that the distribution of the TCF7L2 rs12255372 genotypes is age-independent.