Figure 9. Pharmacological modulation of glucose triggered action potentials.

A, perforated patch recording of a GLUTag cell, showing action potentials in the presence of 10 mm glucose are partially or completely abolished by the addition of 10 μm nifedipine (left) or 0.3 μm TTX (right). B, action potential frequency recorded as in A in the presence of 10 mm glucose before (filled bars), during (unfilled bars) and after (filled bars) addition of 0.3 μm TTX or 10 μm nifedipine. The number of cells is indicated above the bars. Error bars represent 1 s.e.m. and significance was tested using Student's t test: ***P < 0.001, *P < 0.05.