Figure 1. Schematic illustration of a computational model of the guinea pig ventricular myocyte.

Membrane ion channel and transporter currents are based on recently developed models (see text for details). Details of CICR are modeled as in Jafri et al. (1998). Force generation is based on the model of Rice et al. (2000). Mitochondrial ATP production is incorporated using the detailed model of Cortassa et al. (2003).