Table 2.
Treatment group | AVP mRNA (%±s.e.m. of Oil-SHOVX controls) | CRH mRNA (%±s.e.m. of Oil-SHOVX controls) | GR mRNA (%±s.e.m. of Oil-SHOVX controls) | POMC mRNA (%±s.e.m. of Oil-SHOVX controls) |
---|---|---|---|---|
Oil-SHOVX | 100 (9) | 100 (12) | 100 (9) | 100 (13) |
Oil-OVXE2 | 101.2 (11) | 97.2 (13) | 96.3 (7) | 114 (15) |
TP-SHOVX | 65.4 (8)*†‡ | 51.5 (10)***††‡ | 150.9 (8)**† | 47.3 (10)***†††‡ |
TP-OVXE2 | 96.3 (11) | 90 (14) | 114.4 (8) | 89.5 (14) |
TP-SHOVX rats demonstrated significantly lower levels of AVP, CRH and POMC mRNA compared to the remaining groups and significantly greater levels of PVN GR mRNA compared to oil-treated controls.
P < 0.05;
P < 0.01.
P < 0.001 compared to oil-SHOVX;
P < 0.05;
P < 0.01;
P < 0.001 compared to oil-OVXE2;
P < 0.05 compared to TP-OVXE2 rats.