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. 2005 Jan 27;563(Pt 3):855–865. doi: 10.1113/jphysiol.2004.077636

Figure 4. Effects of SP desensitization on the NANC EJP in the presence of nifedipine, apamin, atropine and guanethidine.

Figure 4

A, raw recordings of resting membrane potential. Application of SP produced significant membrane depolarization. However, continuous exposure to SP for up to 30 min resulted in slow recovery of resting membrane potential. Ba, control. Bb and Ca, 2 and 4 min after SP. iii and iv in panel Bb and Ca, junction potentials induced by oral NS of 1 and 4 pulses before, 2 and 20 min after administration of SP, respectively. The EJP amplitude was significantly inhibited and resting membrane potential was depolarized by application of SP for 2 min. However, the EJP amplitude slowly recovered to baseline despite continuous exposure to SP, suggesting that the EJP is resistant to SP desensitization.