Table 1.

Rise and decay time constants of NMDAR currents in WT and GlyT1+/− CA1 pyramidal cells recorded in the absence and presence of glycine at −70 mV

	Low Mg 2+ ACSF* (–Glycine)				+Glycine†
	Activation	Deactivation			Activation	Deactivation
+70mV	τact(ms)	τf‡(ms)	τs‡(ms)	τmean‡(ms)	τact(ms)	τf(ms)	τs(ms)	τmean‡(ms)
WT	7.44 ± 0.6 n = 27	56.73 ± 3.91 n = 27	433.02 ± 66.02 n = 27	142.48 ± 20.83 n = 27	9.97 ± 0.86 n = 5	67.68 ± 7.55 n = 5	512.65 ± 42.46 n = 5	182.65 ± 42.09 n = 5
GlyT1+/−	8.01 ± 0.9 n = 35	38.79 ± 4.12 n = 35	232.73 ± 23.95 n = 35	95.41 ± 5.98 n = 35	9.21 ± 1.76 n = 13	43.12 ± 7.27 n = 13	257.18 ± 37.48 n = 13	102.71 ± 6.41 n = 13

Values are mean ± s.e.m.

^#x002A;Electrically evoked NMDAR currents were recorded in a low Mg²⁺ ACSF (0.1 mm) in the presence of NBQX (20 μm), picrotoxin (50 μm), CGP 52432 (10 μm) and strychnine (0.5 μm). The fast and slow decay components are designated τ_f and τ_s, the weighted time constant by τ_mean.

^†Electrically evoked NMDAR currents recorded in low Mg²⁺ ACSF as in * plus glycine (10μm);

^‡Significant difference between WT and GlyT1+/− mice (P < 0.05).