Figure 1. Current response to a voltage ramp.
A, the current response (top) from a voltage command (bottom) is shown with a single unclamped spike. Cell was held at −82 mV. B, the I–V relation (ascending ramp only) is shown for a pre-TTX (downward trace) and TTX trial (upward trace). C, leak-subtracted I–V relations are shown for pre-TTX and TTX trials. The shaded area represents the voltage region for PC integration (with respect to 0 pA, dashed line). D, leak-subtracted currents are shown for control (thin lines) and G93A (thick lines) cells. The downward currents are the subtraction of the TTX trial (PCTTX-ins) from pre-TTX and represents PCNa.