Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1971 Dec;43(4):724–731. doi: 10.1111/j.1476-5381.1971.tb07207.x

Interaction in the cerebral metabolism of the biogenic amines

Effect of intravenous infusion of L-tryptophan on tryptophan and tyrosine in brain and body fluids

A T B Moir
PMCID: PMC1665723  PMID: 5152024

Abstract

1. The distribution of the amino-acids tryptophan and tyrosine has been determined in plasma ultrafiltrate, whole plasma, erythrocytes, cerebrospinal fluid (c.s.f.) and various regions of the brain in dogs.

2. The effect of tryptophan administration on the distribution of both these amino-acids showed that the alterations produced in tryptophan concentration did not appear to change the concentrations of tyrosine from their normal pattern.

3. The implications of these results with regard to amino-acid transport systems in man and dog are discussed.

Full text

PDF
724

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashcroft G. W., Eccleston D., Crawford T. B. 5-hydroxyindole metabolism in rat brain. A study of intermediate metabolism using the technique of tryptophan loading. I. Methods. J Neurochem. 1965 Jun;12(6):483–492. doi: 10.1111/j.1471-4159.1965.tb06775.x. [DOI] [PubMed] [Google Scholar]
  2. Eccleston D., Ashcroft G. W., Moir A. T., Parker-Rhodes A., Lutz W., O'Mahoney D. P. A comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid. J Neurochem. 1968 Sep;15(9):947–957. doi: 10.1111/j.1471-4159.1968.tb11637.x. [DOI] [PubMed] [Google Scholar]
  3. Elwyn D. H. Distribution of amino acids between plasma and red blood cells in the dog. Fed Proc. 1966 May-Jun;25(3):854–861. [PubMed] [Google Scholar]
  4. GAL E. M., MORGAN M., CHATTERJEE S. K., MARSHALL F. D., Jr HYDROXYLATION OF TRYPTOPHAN BY BRAIN TISSUE IN VIVO AND RELATED ASPECTS OF 5-HYDROXYTRYPTAMINE METABOLISM. Biochem Pharmacol. 1964 Dec;13:1639–1653. doi: 10.1016/0006-2952(64)90218-7. [DOI] [PubMed] [Google Scholar]
  5. GUROFF G., UDENFRIEND S. Studies on aromatic amino acid uptake by rat brain in vivo. Uptake of phenylalanine and of tryptophan; inhibition and stereoselectivity in the uptake of tyrosine by brain and muscle. J Biol Chem. 1962 Mar;237:803–806. [PubMed] [Google Scholar]
  6. Geddes C., Moir A. T. The removal of L-tryptophan from cerebrospinal fluid in the dog. Br J Pharmacol. 1969 May;36(1):204P–205P. [PMC free article] [PubMed] [Google Scholar]
  7. HESS S. M., UDENFRIEND S. A fluorometric procedure for the measurement of tryptamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:175–177. [PubMed] [Google Scholar]
  8. MCMENAMY R. H., LUND C. C., VAN MARCKE J., ONCLEY J. L. The binding of L-tryptophan in human plasma at 37 degrees C. Arch Biochem Biophys. 1961 Apr;93:135–139. doi: 10.1016/0003-9861(61)90325-3. [DOI] [PubMed] [Google Scholar]
  9. McMENAMY R. H., LUND C. C., ONCLEY J. L. Unbound amino acid concentrations in human blood plasmas. J Clin Invest. 1957 Dec;36(12):1672–1679. doi: 10.1172/JCI103568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McMENAMY R. H., ONCLEY J. L. The specific binding of L-tryptophan to serum albumin. J Biol Chem. 1958 Dec;233(6):1436–1447. [PubMed] [Google Scholar]
  11. McMenamy R. H., Lund C. C., Neville G. J., Wallach D. F. STUDIES OF UNBOUND AMINO ACID DISTRIBUTIONS IN PLASMA, ERYTHROCYTES, LEUKOCYTES AND URINE OF NORMAL HUMAN SUBJECTS. J Clin Invest. 1960 Nov;39(11):1675–1687. doi: 10.1172/JCI104191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Moir A. T. Interaction in the cerebral metabolism of the biogenic amines: effect of intravenous infusion of L-tryptophan on the metabolism of dopamine and 5-hydroxyindoles in brain and cerebrospinal fluid. Br J Pharmacol. 1971 Dec;43(4):715–723. doi: 10.1111/j.1476-5381.1971.tb07206.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Moir A. T., Yates C. M. Actions of phenelzine on the interactions of the metabolism of tryptophan and dopamine in brain. Br J Pharmacol. 1970 Nov;40(3):563P–564P. [PMC free article] [PubMed] [Google Scholar]
  14. Tagliamonte A., Tagliamonte P., Perez-Cruet J., Gessa G. L. Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nat New Biol. 1971 Jan 27;229(4):125–126. doi: 10.1038/newbio229125a0. [DOI] [PubMed] [Google Scholar]
  15. WAALKES T. P., UDENFRIEND S. A fluorometric method for the estimation of tyrosine in plasma and tissues. J Lab Clin Med. 1957 Nov;50(5):733–736. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES