Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1972 May;45(1):21–28. doi: 10.1111/j.1476-5381.1972.tb09572.x

The presence of β-adrenoceptors in the guinea-pig seminal vesicle

M Spedding, D F Weetman
PMCID: PMC1666210  PMID: 4402824

Abstract

1. The preparation of longitudinal smooth muscle strips from guinea-pig seminal vesicles is described.

2. Isoprenaline and salbutamol inhibited contractions produced by parasympathomimetic agents.

3. The inhibitory action of isoprenaline was blocked by low concentrations of propranolol and butoxamine. It was concluded that β2-adrenoceptors were present in the tissue.

4. The inhibitory action of isoprenaline was not apparent when adrenaline, noradrenaline, hypogastric nerve or transmural stimulation were used to contract the tissue.

Full text

PDF
21

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENTLEY G. A., SABINE J. R. THE EFFECTS OF GANGLION-BLOCKING AND POSTGANGLIONIC SYMPATHOLYTIC DRUGS ON PREPARATIONS OF THE GUINEA-PIG VAS DEFERENS. Br J Pharmacol Chemother. 1963 Aug;21:190–201. doi: 10.1111/j.1476-5381.1963.tb01515.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BICKERTON R. K. THE RESPONSE OF ISOLATED STRIPS OF CAT SPLEEN TO SYMPATHOMIMETIC DRUGS AND THEIR ANTAGONISTS. J Pharmacol Exp Ther. 1963 Oct;142:99–110. [PubMed] [Google Scholar]
  3. BIRMINGHAM A. T., WILSON A. B. PREGANGLIONIC AND POSTGANGLIONIC STIMULATION OF THE GUINEA-PIG ISOLATED VAS DEFERENS PREPARATION. Br J Pharmacol Chemother. 1963 Dec;21:569–580. doi: 10.1111/j.1476-5381.1963.tb02024.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BURN J. H., RAND M. J. The relation of circulating noradrenaline to the effect of sympathetic stimulation. J Physiol. 1960 Feb;150:295–305. doi: 10.1113/jphysiol.1960.sp006388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Choo-Kang Y. F., Parker S. S., Grant I. W. Response of asthmatics to isoprenaline and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1970 Nov 21;4(5733):465–468. doi: 10.1136/bmj.4.5733.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cullum V. A., Farmer J. B., Jack D., Levy G. P. Salbutamol: a new, selective beta-adrenoceptive receptor stimulant. Br J Pharmacol. 1969 Jan;35(1):141–151. doi: 10.1111/j.1476-5381.1969.tb07975.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Davis W. G. The reversal of phenoxybenzamine-produced alpha-adrenoceptor blockade by the isomers of propranolol and INPEA. J Pharm Pharmacol. 1971 May;23(5):332–338. doi: 10.1111/j.2042-7158.1971.tb09923.x. [DOI] [PubMed] [Google Scholar]
  8. Day M. D., Dixon H. V. The action of isoprenaline on the perfused vessels of the rabbit ear. J Pharm Pharmacol. 1971 Feb;23(2):98–101. doi: 10.1111/j.2042-7158.1971.tb08619.x. [DOI] [PubMed] [Google Scholar]
  9. Dunlop D., Shanks R. G. Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmacol Chemother. 1968 Jan;32(1):201–218. doi: 10.1111/j.1476-5381.1968.tb00444.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Eyre P. Isoprenaline stimulates -adrenoceptors in bovine pulmonary blood vessels. J Pharm Pharmacol. 1971 Nov;23(11):899–900. doi: 10.1111/j.2042-7158.1971.tb10217.x. [DOI] [PubMed] [Google Scholar]
  11. FALCK B., OWMAN C., SJOSTRAND N. O. PERIPHERALLY LOCATED ADRENERGIC NEURONS INNERVATING THE VAS DEFERENS AND THE SEMINAL VESICLE OF THE GUINEA-PIG. Experientia. 1965 Feb 15;21:98–100. doi: 10.1007/BF02144766. [DOI] [PubMed] [Google Scholar]
  12. Ganguly D. K., Bhattacharya B. B. Adrenergic beta receptors in vas deferens. Arch Int Pharmacodyn Ther. 1970 Jun;185(2):406–412. [PubMed] [Google Scholar]
  13. Gay W. S., Rand M. J., Wilson J. Mechanism of the vasoconstrictor action of isoprenaline on an isolated artery preparation. J Pharm Pharmacol. 1967 Jul;19(7):468–473. doi: 10.1111/j.2042-7158.1967.tb08111.x. [DOI] [PubMed] [Google Scholar]
  14. Guimarães S. Reversal by pronethalol of dibenamine blockade: a study on the seminal vesicle of the guinea-pig. Br J Pharmacol. 1969 Jul;36(3):594–601. doi: 10.1111/j.1476-5381.1969.tb08014.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HOLMAN M. E., JOWETT A. SOME ACTIONS OF CATECHOLAMINES ON THE SMOOTH MUSCLE OF THE GUINEA-PIG VAS DEFERENS. Aust J Exp Biol Med Sci. 1964 Feb;42:40–53. doi: 10.1038/icb.1964.4. [DOI] [PubMed] [Google Scholar]
  16. LANDS A. M., BROWN T. G., Jr A COMPARISON OF THE CARDIAC STIMULATING AND BRONCHODILATOR ACTIONS OF SELECTED SYMPATHOMIMETIC AMINES. Proc Soc Exp Biol Med. 1964 Jun;116:331–333. doi: 10.3181/00379727-116-29239. [DOI] [PubMed] [Google Scholar]
  17. LARGE B. J. SYMPATHETIC BETA-RECEPTORS AND THE GUINEA-PIG VAS DEFERENS. Br J Pharmacol Chemother. 1965 Feb;24:194–204. doi: 10.1111/j.1476-5381.1965.tb02095.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G., Jr Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967 May 6;214(5088):597–598. doi: 10.1038/214597a0. [DOI] [PubMed] [Google Scholar]
  19. Lands A. M., Luduena F. P., Buzzo H. J. Differentiation of receptors responsive to isoproterenol. Life Sci. 1967 Nov 1;6(21):2241–2249. doi: 10.1016/0024-3205(67)90031-8. [DOI] [PubMed] [Google Scholar]
  20. Levy B. The adrenergic blocking activity of N-tert.-butylmethoxamine (butoxamine). J Pharmacol Exp Ther. 1966 Mar;151(3):413–422. [PubMed] [Google Scholar]
  21. MCEWEN L. M. The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain. J Physiol. 1956 Mar 28;131(3):678–689. doi: 10.1113/jphysiol.1956.sp005493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Naimzada M. K. Response of the guinea-pig isolated seminal vesicle to stimulation of the hypogastric nerve. Med Pharmacol Exp Int J Exp Med. 1966;15(6):561–567. doi: 10.1159/000135919. [DOI] [PubMed] [Google Scholar]
  23. OHLIN P., STROMBLAD B. C. Observations on the isolated vas deferens. Br J Pharmacol Chemother. 1963 Apr;20:299–306. doi: 10.1111/j.1476-5381.1963.tb01469.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Palmer K. N., Diament M. L. Effect of salbutamol on spirometry and blood-gas tensions in bronchial asthma. Br Med J. 1969 Jan 4;1(5635):31–32. doi: 10.1136/bmj.1.5635.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Saxena P. R. Effect of some drugs on the responses of the vas deferens and seminal vesicle to hypogastric nerve stimulation in guinea-pig in vivo. Pharmacology. 1970;3(4):220–228. doi: 10.1159/000136076. [DOI] [PubMed] [Google Scholar]
  26. Thoa N. B., Maengwyn-Davies G. D. The guinea-pig isolated vas deferens: a method for increasing sensitivity to drugs. J Pharm Pharmacol. 1968 Nov;20(11):873–876. doi: 10.1111/j.2042-7158.1968.tb09664.x. [DOI] [PubMed] [Google Scholar]
  27. Wakade A. R., Kirpekar S. M. Chemical and histochemical studies on the sympathetic innervation of the vas deferens and seminal vesicle of the guinea pig. J Pharmacol Exp Ther. 1971 Sep;178(3):432–441. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES