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. 2006 Sep 25;174(7):1097–1106. doi: 10.1083/jcb.200511134

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Copyright © 2006, The Rockefeller University Press

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Figure 9. — Proposed model of epithelial cell targeting by lacritin. Deglycanated core protein of SDC1 targets the epithelial selective prosecretory mitogen lacritin. (i) Binding requires prior partial or complete removal of HS chains by endogenous HPSE1. (ii) Binding is mutually specified by lacritin's C-terminal mitogenic domain and SDC1's N terminus.