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. 1975 Nov;55(3):351–358. doi: 10.1111/j.1476-5381.1975.tb06938.x

Behavioural changes induced in conscious mice by intracerebroventricular injection of catecholamines, acetylcholine and 5-hydroxytryptamine.

Z S Herman
PMCID: PMC1666689  PMID: 1203622

Abstract

1 A simple method of injecting soluble substances into the lateral ventricle of the brain of the conscious mouse is described. 2 The effect of various doses of noradrenaline, dopamine, acetylcholine, 5-hydroxytryptamine given into the right lateral brain ventricle were tested on locomotor and exploratory activities of mice. 3 Noradrenaline in a dose of 0.1 mug increased locomotor activity. This effect was prevented by phenoxybensamine but not by propranolol. 4 Higher doses of noradrenaline (1 or 10 mug) decreased locomotor and exploratory activities. Propranolol but not phenoxybenzamine abolished these effects. 5 Dopamine (0.1 or 1 mug) increased locomotor activity. The higher doses also induced tremor. 6 The highese dose of dopamine tested (10 mug) elicited stereotypical behaviour. 7 All the behavioural phenomena induced by 0.1 mug and 10 mug of dopamine were blocked by pimozide. 8 Acetylcholine (1 and 10 mug) and 5-hydroxytryptamine (1 mug) inhibited locomotor and exploratory activity. 9 The effects of 1 and 10 mug of acetylcholine were abolished by atropine (5 mg/kg i.p. Methysergide (5 mg/kg i.p.) had no influence on the effects of 5-hydroxytryptamine (1 mug).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andén N. E., Butcher S. G., Corrodi H., Fuxe K., Ungerstedt U. Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur J Pharmacol. 1970;11(3):303–314. doi: 10.1016/0014-2999(70)90006-3. [DOI] [PubMed] [Google Scholar]
  2. Andén N. E., Strömbom U. Adrenergic receptor blocking agents: effects on central noradrenaline and dopamine receptors and on motor activity. Psychopharmacologia. 1974;38(2):91–103. doi: 10.1007/BF00426104. [DOI] [PubMed] [Google Scholar]
  3. Benkert O., Köhler B. Intrahypothalamic and intrastriatal dopamine and norepinephrine injections in relation to motor hyperactivity in rats. Psychopharmacologia. 1972;24(2):318–325. doi: 10.1007/BF00403650. [DOI] [PubMed] [Google Scholar]
  4. Boakes R. J., Bradley P. B., Briggs I., Dray A. Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25. Br J Pharmacol. 1970 Oct;40(2):202–218. doi: 10.1111/j.1476-5381.1970.tb09914.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FELDBERG W., SHERWOOD S. L. Injections of drugs into the lateral ventricle of the cat. J Physiol. 1954 Jan;123(1):148–167. doi: 10.1113/jphysiol.1954.sp005040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grunden L. R., Marley E. Effects of sympathomimetic amines injected into the third cerebral ventricle in adult chickens. Neuropharmacology. 1970 Mar;9(2):119–128. doi: 10.1016/0028-3908(70)90055-9. [DOI] [PubMed] [Google Scholar]
  7. Herman Z. S. Influence of noradrenaline, 5-hydroxytryptamine and acetylcholine injected intraventricularly on the rat's behaviour. Acta Physiol Pol. 1973 Jan-Feb;24(1):87–91. [PubMed] [Google Scholar]
  8. Herman Z. S., Kmieciak-Kolada K., Slominska-Zurek J., Szkilnik R. Central effects of acetylcholine. Psychopharmacologia. 1972;27(3):223–232. doi: 10.1007/BF00422802. [DOI] [PubMed] [Google Scholar]
  9. Herman Z. S. The effects of noradrenaline on rat's behaviour. Psychopharmacologia. 1970;16(5):369–374. doi: 10.1007/BF00404847. [DOI] [PubMed] [Google Scholar]
  10. LEIMDORFER A. The action of sympathomimetic amines on the central nervous system and the blood sugar; relation of chemical structure to mechanism of action. J Pharmacol Exp Ther. 1950 Jan;98(1):62–71. [PubMed] [Google Scholar]
  11. Malec D., Kleinrok Z. The spontaneous motility of rats after intraventricular injection of dopamine. Neuropharmacology. 1972 May;11(3):331–336. doi: 10.1016/0028-3908(72)90018-4. [DOI] [PubMed] [Google Scholar]
  12. Marley E., Stephenson J. D. Effects of catecholamines infused into the brain of young chickens. Br J Pharmacol. 1970 Dec;40(4):639–658. doi: 10.1111/j.1476-5381.1970.tb10644.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marley E., Stephenson J. D. Effects of some catecholamines infused into the hypothalamus of young chickens. Br J Pharmacol. 1969 May;36(1):194P–195P. [PMC free article] [PubMed] [Google Scholar]
  14. McKeon W. B., Jr In vivo antiserotonin activity in the unanesthetized guinea pig. Arch Int Pharmacodyn Ther. 1967 Aug;168(2):373–382. [PubMed] [Google Scholar]
  15. PALMER A. C. Injection of drugs into the cerebral ventricle of sheep. J Physiol. 1959 Dec;149:209–214. doi: 10.1113/jphysiol.1959.sp006335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SCHAIN R. J. Some effects of a monoamine oxidase inhibitor upon changes produced by centrally administered amines. Br J Pharmacol Chemother. 1961 Oct;17:261–266. doi: 10.1111/j.1476-5381.1961.tb01286.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Segal D. S., Mandell A. J. Behavioral activation of rats during intraventricular infusion of norepinephrine. Proc Natl Acad Sci U S A. 1970 Jun;66(2):289–293. doi: 10.1073/pnas.66.2.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stern J. J., Zwick G. Effects of intraventricular norepinephrine and estradiol benzoate on weight regulatory behavior in female rats. Behav Biol. 1973 Nov;9(5):605–612. doi: 10.1016/s0091-6773(73)80054-9. [DOI] [PubMed] [Google Scholar]
  19. TRACZYK W. Z. EXPERIMENTAL CATALEPSY PRODUCED IN DOGS BY INTRAVENTRICULAR ADMINISTRATION OF ADRENALINE AND NORADRENALINE. Int J Neuropharmacol. 1964 May;3:261–266. doi: 10.1016/0028-3908(64)90015-2. [DOI] [PubMed] [Google Scholar]
  20. WADA J. A. Behavioral and electrographic effects of intraventricular injection of bulbocapnine and other substances in freely moving monkeys. Ann N Y Acad Sci. 1962 Jan 13;96:227–250. doi: 10.1111/j.1749-6632.1962.tb50119.x. [DOI] [PubMed] [Google Scholar]

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