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. 2006 Nov;174(3):1517–1528. doi: 10.1534/genetics.106.060723

TABLE 3.

Comparison between haplotype and genotype data: performance for models with uniform recombination rates with unphased data

γa ρa g(γ)b g(ρ)b B(γ)c B(ρ)c E(Inline graphic)d E(Inline graphic)d V(γ)e V(ρ)e
Hudson's composite-likelihood method
20 20 0.452 0.968 0.600 0.573 22.060 20.170 1.273 0.495
60 20 0.692 0.954 0.545 0.491 55.259 21.594 0.650 0.573
80 20 0.794 0.962 0.626 0.543 74.119 20.908 0.534 0.564
20 40 0.420 0.968 0.662 0.484 19.919 42.000 1.345 0.426
40 40 0.572 0.960 0.619 0.534 36.620 40.880 0.863 0.417
Summary statistics method
20 20 0.580 0.910 0.445 0.498 27.600 22.700 1.387 0.715
60 20 0.732 0.850 0.454 0.453 70.278 24.090 0.763 0.822
80 20 0.748 0.838 0.468 0.514 89.940 23.226 0.654 0.872
20 40 0.488 0.904 0.516 0.521 28.076 42.582 1.673 0.512
40 40 0.600 0.828 0.501 0.541 51.814 43.050 1.169 0.590
a

γ and ρ denote the true values of the gene-conversion and crossing-over rates under which 500 data sets were simulated.

b

g(γ) and g(ρ) denote the fraction of the data sets for which the estimates of gene conversion (Inline graphic) and crossing over (Inline graphic) lie within a factor of 2 of the true values (i.e., γ and ρ), respectively.

c

B(γ) and B(ρ) denote the fraction of times the estimates of gene conversion and crossing over are lower than the true values, given that they are not equal to the true values.

d

E(Inline graphic) and E(Inline graphic) denote the mean of the estimates of gene-conversion and crossing-over rates.

e

V(γ) and V(ρ) denote the root mean square relative error for the estimates.