TABLE 2.
Factors tested in linear models used to evaluate systemic bacterial load (see materialsandmethods)
| Factor name | Effect type | Effect measured |
|---|---|---|
| Linei (i = 1, 95) | Fixed | Overall genetic contribution to phenotype |
| Sexj (j = 1, 2) | Fixed | Sex of the infected flies |
| Dayk (k = 1, 3) | Random | Day-to-day variability in delivery of infection |
| Markerl (l = 1, 2) | Fixed | Allelic state at a focal marker |
| Pathogenp (p = 1, 4) | Fixed | Bacterium used in challenge |
| (Line × Sex)ij | Random | Variation among sexes in the effect of background genetic variation |
| (Sex × Day)jk | Random | Variation among sexes in day-to-day variability in resistance to infection |
| (Sex × Marker)jl | Fixed | Variation among sexes in the effect of a focal marker |
| (Sex × Pathogen)jp | Fixed | Variation among sexes in resistance to infection by one or more bacteria |
| (Marker × Pathogen)lp | Fixed | Variation among pathogens in the effect of a focal marker |
| (Sex × Marker × Pathogen)jlp | Fixed | Variation among sexes in pathogen-specific effects of a focal marker |
| (Marker × Marker)lm | Fixed | Nonadditive (epistatic) interactions between two markers |
| (Sex × Marker × Marker)jlm | Fixed | Variation among sexes in nonadditive (epistatic) interactions between two markers |
| Linei (Markerl) | Random | Background genetic variation segregating within genotypes of a focal marker |
| Linei (Markerl × Markerm) | Random | Background genetic variation segregating within a two-locus genotype |
| Dayk (Pathogenp) | Random | Day-to-day variability in infection with a given pathogen |