Figure 3.—

Sequence comparisons of Drosophila Mus301 with other Mus308 subfamily helicases. (A) The complete sequence of D. melanogaster Mus301 was compared to that of Dm Mus308, human HEL308, mouse HEL308, and C. elegans Y55B1AL.3a. The percentages of similarity and identity (in parentheses) are indicated. (B) Percentages of similarity and identity (in parentheses) in the helicase region of Dm Mus301 and that of other homologs. Solid boxes represent the SF2 helicase motifs present in Dm Mus301. Dm Mus308 is not drawn to scale. (C) Phylogenetic analysis of Dm Mus301 and related proteins. The tree-building method was “neighbor joining,” using the ‘best tree’ mode; numbers represent uncorrected distances. The Drosophila helicase L(2)35Df is a divergent member of the Mus308 subfamily and is shown for comparison.