TABLE 2.

Quantitative trait loci for diabetes-associated traits identified by multiple-marker QTL analysis

QTL	Marker ± SI (Mb)a	Trait	LRb	Nominal P-value	Effectc ± SE	Vard %	No. of genese
Niddm1i1	D1Rat83 + 0.8	Bw	11.0**	1 × 10−3	−6.8 ± 2.0	5.1	13
Niddm1i2	D1Swe2 ± 0.25	G15	8.5*	3 × 10−3	+2.4 ± 0.8	4.0	2
		G30	4.1	0.04	+1.4 ± 0.7	2.0
Niddm1i3	D1Got244 ± 0.2	G15	8.3*	4 × 10−3	−2.6 ± 0.9	3.9	1
		G30	4.3	0.04	−1.5 ± 0.7	2.1
Niddm1i4	D1Smu2 ± 0.35	G15	20.9***	5 × 10−6	+2.2 ± 0.5	9.6	7
		G30	15.6**	8 × 10−5	+1.5 ± 0.4	7.2

Bw, body weight (grams); G15, postprandial glucose at 15 min, and, G30 at 30 min in mmol/liter.

^aSI for QTL support intervals estimated by the 1.5-LOD drop method; Mb, megabase pair.

^bLR denotes the likelihood ratio test statistic for QTL and level of significance: *suggestive experiment-wise significance (α = 0.2); **significant experiment-wise significance (α = 0.05); ***highly significant experiment-wise significance (α = 0.001).

^cAdditive effect defined as AA-BB/2, where AA is the genotypic value for GK homozygotes at the QTL, and BB is the genotypic value for F344 homozygotes; SE, standard error.

^dVar is percentage of phenotypic residual variance explained by the QTL.

^eThe number of positional candidate genes within the QTL interval using NCBI assembly 3.4 of the rat genome.