TABLE 1.

Molecular characterization of Su(var)2-HP2 lethal mutations

Allele	Line	Location	Exon	Base change	Amino acid change	Su(var)
288a	288	588	6	C → T	Thr → Iso	3
Q714X	E456	714	6	C → T	Gln → stop	2
Q770X	J916	770	6	C → T	Gln → stop	3
Q895X	I308	895	6	C → T	Gln → stop	2
R920X	L606	920	6	C → T	Arg → stop	0
C1070X	J125	1070	6	C → T	Cys → stop	3
Q1187X	C272	1187	6	T → A	Gln → stop	1
Q2097X	C13	2097	8	C → T	Gln → stop	1
Q2259X	D143	2259	8	C → T	Gln → stop	1
692a	692	2370	8	A insertion	28 aa then stop	0
C2540X	H910	2540	8	T → A	Cys → stop	0
Q2543X	E814	2543	8	C → T	Gln → stop	0
R2750X	I668	2753	8	C → T	Arg → stop	0
P2763L	G572	2763	8	C → T	Pro → Leu	3
Q2885X	J936	2885	8	C → T	Gln → stop	0
Q2899X	C354	2899	8	C → T	Gln → stop	0
230a	230	3220	9	A → T	Asp → Iso	2

Alleles are named by indicating the altered amino acid followed by its sequence position and the resulting amino acid, where “X” indicates a stop codon. Location is based on the protein sequence accession NP_610972. See Figure 5 for Su(var) levels.

^aAlleles from these lines, reported here for completeness, were originally described in Shaffer et al. (2002).