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. 2000 Jun 20;97(14):8140–8145. doi: 10.1073/pnas.120035997

Figure 4.

Figure 4

Responses to thermal (A and B) and chemical (C and D) noxious stimuli. Thermal nociception was tested in the tail-flick (A) and the hot-plate test at three different temperatures (B) and chemical nociception by intradermal injection of formalin (2.5%) (C) and capsaicin (1.6 mg) (D) in wild-type (+/+) and B1-deficient mice (−/−). Data are means ± SEM and were analyzed by analysis of variance followed by Dunnetts' test (n = 4–6). ***, P < 0.001; **, P < 0.01; *, P < 0.05 compared with +/+ animals.