Figure 2.

Selection pressure interaction map. The degree to which a mutation at one site X (horizontal axis) affects the selection pressure at another site Y (vertical axis) is shown as the condtional selection ratio for all amino acid mutations at site Y conditioned on any amino acid mutation at site X. The color coding scale indicates increasing values of positive conditional selection ratio. Interactions showing conditional selection ratios >1 (positive conditional selection) with LOD scores >3 are shown, with blue indicating stronger interactions and yellow indicating weaker ones. Clicking any particular square provides details on the numbers used in the calculation.