TABLE 2.
Reovirus-induced alteration in expression of genes encoding proteins known to be involved in DNA repair
| Gene | GenBank accession no.a | Change in expression (n-fold)b at the indicated time (h) after infection with:
|
|||
|---|---|---|---|---|---|
| T3A
|
T1L | ||||
| 6 | 12 | 24 | 24 | ||
| DNA ligase 1 | M36067 | −8.2 ± 1.1 | |||
| PARPL | AF057160 | −6.3 ± 0.7 | |||
| XP-C repair complementing protein (p125) | D21089 | −3.4 ± 0.1 | |||
| DNA polymerase gamma | U60325 | −1.9 ± 0.1 | −2.9 ± 0.1 | ||
| ERCC5 | L20046 | −2.7 ± 0.1 | |||
| DNA polymerase alpha | L24559 | −2.5 ± 0.2 | |||
| HLP (helicase-like protein) | U09877 | −2.4 ± 0.1 | |||
| GTBP | U28946 | −2.0 ± 0.1 | −2.1 ± 0.0 | ||
| DDB2 (p48 subunit) | U18300 | −2.0 ± 0.0 | |||
| RAD 54 homologue | X97795 | −2.0 ± 0.1 | |||
| Mi2 autoantigen | X86691 | −1.3 ± 0.1 | −2.0 ± 0.1 | ||
| MMS2 | AF049140 | 2.1 ± 0.0 | |||
| Rad-51-interacting protein | AF006259 | 2.6 ± 0.2 | |||
| Rec-1 | AF084513 | 2.4 ± 0.4 | |||
a
GenBank accession number corresponds to sequence from which the Affymetrix U95A probe set was designed.
b
Data are means ± standard errors of the means.