TABLE 2.
Proliferative responses of immunized macaques to SIV gp120 and p27
| Response type and macaque groupa | Post-first Ad5hr recombinants (wk 6)
|
Post-second Ad5hr recombinants (wk 18)
|
Post-first gp120 (wk 30)
|
|||
|---|---|---|---|---|---|---|
| No. positive/no. tested (%) | Mean SI ± SEMb | No. positive/no. tested (%) | Mean SI ± SEM | No. positive/no. tested (%) | Mean SI ± SEM | |
| SIV gp120 responses | ||||||
| I, E/R | 0/8 (0) | 0 | NDc | ND | 4/8 (50) | 4.2 ± 1.0 |
| II, E/R+G | 0/7 (0) | 0 | 1/7 (14) | 2.4 | ND | ND |
| III, E/R+N | 1/8 (12) | 2.2 | 5/8 (63) | 4.1 ± 0.7 | 4/8 (50) | 3.4 ± 0.2 |
| IV, E/R+G+N | 2/8 (25) | 2.2 ± 0.2 | 4/8 (50) | 3.6 ± 0.6 | 5/8 (63) | 3.5 ± 0.7 |
| SIV p27 responses | ||||||
| II, E/R+G | 0/7 (0) | 0 | 2/7 (29) | 3.2 ± 0.8 | ND | ND |
| IV, E/R+G+N | 4/8 (50) | 4.0 ± 0.7 | 4/8 (50) | 4.8 ± 1.6 | 5/8 (63) | 3.8 ± 0.9 |
a
Ad5hr-SIV recombinant inserted genes are abbreviated E/R for env/rev, G for gag, and N for nef.
b
Mean SI ± the standard error of the mean (SEM) values are reported for positive responders only.
c
ND, not determined.