TABLE 2.
IC50s of various recombinant viruses for antiviral nucleosidesa
| Virus | TCID50/ml | ABC
|
ddI
|
d4T
|
3TC
|
||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 (μM) | Fold resistance | IC50 (μM) | Fold resistance | IC50 (μM) | Fold resistance | IC50 (μM) | Fold resistance | ||
| WT | 1.23 × 108 | 0.15 ± 0.1 | 0.72 ± 0.1 | 1.64 ± 0.4 | 0.6 ± 0.3 | ||||
| 74V | 3.24 × 106 | 1.18 ± 0.2 | 7.8 | 4.91 ± 0.6 | 6.8 | 2.82 ± 0.4 | 1.7 | 2.43 ± 0.3 | 4.1 |
| 184V | 3.05 × 106 | 1.22 ± 0.2 | 8 | 6.79 ± 0.1 | 9.4 | 1.29 ± 0.2 | >100 | >150 | |
| 74V-184V | 5.94 × 105 | 4.27 ± 0.1 | 28 | 17.16 ± 0.8 | 24 | 2.14 ± 0.3 | 1.3 | >100 | >150 |
a
Values are means from at least three independent experiments ± standard errors.