TABLE 1.

TTV genogroups detected in plasma samples of 32 study children found TTV positive by universal PCR

Category	No. of children	Log10 TTV DNA copies/ml (mean ± SD)	Circulating lymphocytes (mean ± SD)
			% CD3 cells	% CD4 cells	% CD19 cells
TTV genogroup present
Genogroup 1	16	8.1 ± 1.4a	47.1 ± 9.5	28.3 ± 7.5	25.7 ± 13.7
Genogroup 2	2	9.5 ± 2.2	48.5 ± 5.2	28.9 ± 4.7	20.2 ± 6.1
Genogroup 3	21	7.8 ± 1.4	47.3 ± 8.3b	28.2 ± 6.2c	27.2 ± 12.7
Genogroup 4	13	7.7 ± 1.9	50.9 ± 10.0	30.6 ± 6.5	26.1 ± 13.7
Genogroup 5	5	8.2 ± 1.5	50.7 ± 6.8	30.6 ± 2.9	32.1 ± 9.5
Untyped TTVd	5	7.6 ± 1.2	50.7 ± 12.3	32.4 ± 7.4	32.2 ± 19.5
No. of TTV genogroups
1	8	6.2 ± 0.9e	56.4 ± 7.1f	34.5 ± 6.3g	18.8 ± 9.8
2	12	7.5 ± 1.1	46.6 ± 7.3	27.5 ± 7.2	24.7 ± 12.1
3	3	7.6 ± 1.3	43.4 ± 14.9	27.0 ± 8.0	33.2 ± 19.6
4	4	9.6 ± 1.3	49.9 ± 7.1	29.7 ± 2.6	30.0 ± 11.6

^aStatistically different from the value for the 16 children who had TTV genogroups other than genogroup 1 (mean, 6.9 ± 1.2) (P = 0.012 by Student's t test).

^bStatistically different from the value for the 11 children who had TTV genogroups other than genogroup 3 (mean, 54.6 ± 9.8) (P = 0.04 by Student's t test).

^cStatistically different from the value for the 11 children who had TTV genogroups other than genogroup 3 (mean, 34.1 ± 7.0) (P = 0.03 by Student's t test).

^dSpecimens which gave positive results by universal PCR but gave negative results by all five genogroup-specific PCR assays.

^eStatistically different from the value for the 19 children who tested positive for two or more genogroups (mean, 8.0 ± 1.4) (P = 0.0007 by Student's t test).

^fStatistically different from the value for the 19 children who tested positive for two or more genogroups (mean, 46.8 ± 8.3) (P = 0.008 by Student's t test).

^gStatistically different from the value for the 19 children who tested positive for two or more genogroups (mean, 27.9 ± 6.4) (P = 0.025 by Student's t test).