FIG. 6.

VSV-IFNβ is attenuated in vivo. (A) Various amounts of VSV-IFNβ, VSV-GFP, or rVSV without an insert or wild-type (WT) VSV (Indiana strain) were used for i.v. inoculation of BALB/c mice (6 to 8 weeks old). Mortality of the animals was monitored. (B) Survival times of animals receiving i.v. inoculations of 10⁸ PFU of VSV-IFNβ, VSV-GFP, or wild-type VSV (Indiana strain). (C) Weights of BALB/c animals that received i.v. inoculations of phosphate-buffered saline or recombinant viruses at the various doses indicated and that were monitored for 12 weeks postinfection. No residual or persistent virus was detected in a variety of organs analyzed at 20 weeks postinfection.