FIG. 8.

Predicted topology and functional motifs of VV A14. A model of membrane-spanning, disulfide-linked dimers of A14 is depicted. The N′ and C′ termini are predicted to be luminal (Lu) upon synthesis in the ER; the hydrophilic loop region is predicted to be cytosolic (Cy). Regions highlighted in red represent essential sequence elements within A14 (N₉YFS and P₃₉TRTWK). The position of Cys₇₁, the residue required for disulfide formation, is indicated by a cyan circle. The overlapping triangles indicate the sites of N-linked glycosylation (Asn₈₃) and phosphorylation (Ser₈₅).