Abstract
In a double-blind study on the value of equine ("natural") oestrogens 30 patients presenting with menopausal symptoms in a group practice were monitored for possible adverse effects on blood clotting, weight, and blood pressure. The women were randomly allocated to two groups and given either three months' hormone treatment followed by three months' placebo or vice versa. An appreciable amelioration of all symptoms on placebo made it difficult to asses the genuine value of oestrogen treatment during the period of study. Both groups made a dramatic clinical improvement during the first three months. Nevertheless, the symptoms of the 15 women who received oestrogen first returned after the cross-over to placebo without any suggestion of a placebo response. In contrast, the other group who took placebo first did not deteriorate after changing to oestrogen. The menopausal index and the karyopyknotic index were not reliable guides to the need for oestrogen treatment. Hot flushes, however, were proportionately reduced on oestrogen and they seemed to be more readily eliminated in individual cases by oestrogen. The results of blood clotting studies indicated that natural oestrogen administration raised the levels of the extrinsic clotting factors VII and X and accelerated the prothrombin time. The findings were similar to those observed after three months synthetic oestrogen administration with oral contraception. Long-term studies and epidemiological surveys of the clinical incidence of thrombotic and other sequelae are needed before large-scale oestrogen replacement treatment can be recommended.
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Selected References
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- Clayden J. R., Bell J. W., Pollard P. Menopausal flushing: double-blind trial of a non-hormonal medication. Br Med J. 1974 Mar 9;1(5905):409–412. doi: 10.1136/bmj.1.5905.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elkeles R. S., Hampton J. R., Mitchell J. R. Effect of oestrogens on human platelet behaviour. Lancet. 1968 Aug 10;2(7563):315–318. doi: 10.1016/s0140-6736(68)90528-x. [DOI] [PubMed] [Google Scholar]
- McKinlay S. M., Jefferys M. The menopausal syndrome. Br J Prev Soc Med. 1974 May;28(2):108–115. doi: 10.1136/jech.28.2.108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poller L., Thomson J. M., Sear C. H., Thomas W. Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma. J Clin Pathol. 1971 Oct;24(7):626–632. doi: 10.1136/jcp.24.7.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poller L., Thomson J. M., Tabiowo A., Priest C. M. Progesterone oral contraception and blood coagulation. Br Med J. 1969 Mar 1;1(5643):554–556. doi: 10.1136/bmj.1.5643.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poller L., Thomson J. M. The partial thromboplastin (cephalin) time test. J Clin Pathol. 1972 Dec;25(12):1038–1044. doi: 10.1136/jcp.25.12.1038. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Poller L., Thomson J. M., Thomas P. W. Effects of progestogen oral contraception with norethisterone on blood clotting and platelets. Br Med J. 1972 Nov 18;4(5837):391–393. doi: 10.1136/bmj.4.5837.391. [DOI] [PMC free article] [PubMed] [Google Scholar]