Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1975 Nov 8;4(5992):316–319. doi: 10.1136/bmj.4.5992.316

Plasma renin activity and aldosterone concentration in children.

M J Dillon, J M Ryness
PMCID: PMC1675185  PMID: 1192047

Abstract

Using semi-micro methods, plasma renin activity (PRA) and plasma aldosterone concentration (PA) were measured concurrently in 79 healthy children aged 1 month to 15 years to establish a reference range. PRA and PA varied inversely with age. Eleven children with renal hypertension had higher PRA and PA than age-matched controls. In contrast, PRA was much greater in 38 saline-depleted children. PA was not uniformly increased in this group and was within the normal range in children with adrenal diseases compared with the high values seen in other salt-wasting states. The findings emphasise the need to relate data from patients to age-matched control values before attempting interpretation and suggest that sodium depletion is a more potent stimulator of renin-aldosterone release than renovascular disease or renal scarring in children. Plasma renin-aldosterone profiles were also valuable in discriminating between renal and adrenal causes of salt loss in childhood.

Full text

PDF
316

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bayard F., Ances I. G., Tapper A. J., Weldon V. V., Kowarski A., Migeon C. J. Transplacental passage and fetal secretion of aldosterone. J Clin Invest. 1970 Jul;49(7):1389–1393. doi: 10.1172/JCI106356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beitins I. Z., Bayard F., Levitsky L., Ances I. G., Kowarski A., Migeon C. J. Plasma aldosterone concentration at delivery and during the newborn period. J Clin Invest. 1972 Feb;51(2):386–394. doi: 10.1172/JCI106824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Broughton Pipkin F., Kirkpatrick S. M., Lumbers E. R., Mott J. C. Renin and angiotensin-like levels in foetal, new-born and adult sheep. J Physiol. 1974 Sep;241(3):575–588. doi: 10.1113/jphysiol.1974.sp010672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Broughton Pipkin F., Mott J. C., Roberton N. R. Angiotensin II-like activity in circulating arterial blood in immature and adult rabbits. J Physiol. 1971 Oct;218(2):385–403. doi: 10.1113/jphysiol.1971.sp009624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Broughton Pipkin F., Smales O. R. Proceedings: Blood pressure and angiotensin II in the newborn. Arch Dis Child. 1975 Apr;50(4):330–330. doi: 10.1136/adc.50.4.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bühler F. R., Laragh J. H., Sealey J. E., Brunner H. R. Plasma aldosterone-renin interrelationships in various forms of essential hypertension. Studies using a rapid assay of plasma aldosterone. Am J Cardiol. 1973 Sep 20;32(4):554–561. doi: 10.1016/s0002-9149(73)80047-5. [DOI] [PubMed] [Google Scholar]
  7. Dillon M. J. Renin and hypertension in childhood. Arch Dis Child. 1974 Nov;49(11):831–834. doi: 10.1136/adc.49.11.831. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Geelhoed G. W., Vander A. J. Plasma renin activities during pregnancy and parturition. J Clin Endocrinol Metab. 1968 Mar;28(3):412–415. doi: 10.1210/jcem-28-3-412. [DOI] [PubMed] [Google Scholar]
  9. Godard C., Riondel A. M., Veyrat R., Mégevand A., Muller A. F. Plasma renin activity and aldosterone secretion in congenital adrenal hyperplasia. Pediatrics. 1968 May;41(5):883–904. [PubMed] [Google Scholar]
  10. Goldberg S., Krishan I., Hames C. B., Knight M., Spierto F. W. Elevated renin levels in normotensive adolescents. Pediatrics. 1974 Nov;54(5):596–598. [PubMed] [Google Scholar]
  11. Granger P., Rojo-Ortega J. M., Casado Pérez S., Boucher R., Genest J. The renin-angiotensin system in newborn dogs. Can J Physiol Pharmacol. 1971 Feb;49(2):134–138. doi: 10.1139/y71-019. [DOI] [PubMed] [Google Scholar]
  12. Haning R., McCracken J., St Cyr M., Underwood R., Williams G., Abraham G. The evolution of titer and specificity of aldosterone binding antibodies in hyperimmunized sheep. Steroids. 1972 Jul;20(1):73–88. doi: 10.1016/0039-128x(72)90119-5. [DOI] [PubMed] [Google Scholar]
  13. Hayduk K., Krause D. K., Huenges R., Unbehaun V. Plasma renin concentration at delivery and during the newborn period in humans. Experientia. 1972 Dec 15;28(12):1489–1490. doi: 10.1007/BF01957872. [DOI] [PubMed] [Google Scholar]
  14. Imai M., Igarashi Y., Sokabe H. Plasma renin activity in congenital virilizing adrenal hyperplasia. Pediatrics. 1968 May;41(5):897–904. [PubMed] [Google Scholar]
  15. Katz F. H., Beck P., Makowski E. L. The renin-aldosterone system in mother and fetus at term. Am J Obstet Gynecol. 1974 Jan 1;118(1):51–55. doi: 10.1016/s0002-9378(16)33645-6. [DOI] [PubMed] [Google Scholar]
  16. Kokot F., Cekański A. Uber das Verhalten der Plasmareninaktivität in der normalen Schwangerschaft, bei Schwangerschaftstoxikosen und im Nabelschnurblut von Neugeborenen. Zentralbl Gynakol. 1970 Feb 28;92(9):280–287. [PubMed] [Google Scholar]
  17. Kotchen T. A., Strickland A. L., Rice T. W., Walters D. R. A study of the renin-angiotensin system in newborn infants. J Pediatr. 1972 Jun;80(6):938–946. doi: 10.1016/s0022-3476(72)80005-2. [DOI] [PubMed] [Google Scholar]
  18. Kowarski A., Katz H., Migeon C. J. Plasma aldosterone concentration in normal subjects from infancy to adulthood. J Clin Endocrinol Metab. 1974 Mar;38(3):489–491. doi: 10.1210/jcem-38-3-489. [DOI] [PubMed] [Google Scholar]
  19. Laragh J. H., Baer L., Brunner H. R., Buhler F. R., Sealey J. E., Vaughan E. D., Jr Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med. 1972 May;52(5):633–652. doi: 10.1016/0002-9343(72)90054-x. [DOI] [PubMed] [Google Scholar]
  20. Londe S., Bourgoignie J. J., Robson A. M., Goldring D. Hypertension in apparently normal children. J Pediatr. 1971 Apr;78(4):569–577. doi: 10.1016/s0022-3476(71)80457-2. [DOI] [PubMed] [Google Scholar]
  21. Mott J. C. The place of the renin-angiotensin system before and after birth. Br Med Bull. 1975 Jan;31(1):44–50. doi: 10.1093/oxfordjournals.bmb.a071240. [DOI] [PubMed] [Google Scholar]
  22. Sassard J., Sann L., Vincent M., Francois R., Cier J. F. Plasma renin activity in normal subjects from infancy to puberty. J Clin Endocrinol Metab. 1975 Mar;40(3):524–525. doi: 10.1210/jcem-40-3-524. [DOI] [PubMed] [Google Scholar]
  23. Siegel S. R., Fisher D. A., Oh W. Renal function and serum aldosterone levels in infants with respiratory distress syndrome. J Pediatr. 1973 Nov;83(5):854–858. doi: 10.1016/s0022-3476(73)80389-0. [DOI] [PubMed] [Google Scholar]
  24. Siegel S. R., Fisher D. A., Oh W. Serum aldosterone concentrations related to sodium balance in the newborn infant. Pediatrics. 1974 Mar;53(3):410–413. [PubMed] [Google Scholar]
  25. Voûte P. A., Jr, van der Meer J., Staugaard-Kloosterziel W. Plasma renin activity in Wilms' tumour. Acta Endocrinol (Copenh) 1971 May;67(1):197–202. doi: 10.1530/acta.0.0670197. [DOI] [PubMed] [Google Scholar]
  26. Whitelaw A. G., Dillon M. J., Tripp J. H. Hypertension, oedema, and suppressed renin aldosterone system due to unsupervised salt administration. Arch Dis Child. 1975 May;50(5):400–401. doi: 10.1136/adc.50.5.400. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES