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. 1975 Dec 13;4(5997):619–621. doi: 10.1136/bmj.4.5997.619

Effect on adrenal function of topically applied clobetasol propionate (Dermovate).

C F Allenby, R A Main, R A Marsden, C G Sparkes
PMCID: PMC1675721  PMID: 1203701

Abstract

Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satisfactory initial therapeutic response was achieved in almost all cases during the trial period. When more than 50 g of ointment a week was used a significant number of patients developed adrenal suppression. WHen less than 50 g per week was used any suppression tended to be transtion. These cysts may be the cause of this condition, producing abnormal amounts of ovarian steroids which modify the pituitary response. Futher studies are needed, however, to determine this possibility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Child K. J., English A. F., Gilbert H. G., Hewitt A., Woollett E. A. Vasoconstrictor and systemic activities of topical steroids. Arch Dermatol. 1968 Apr;97(4):407–410. [PubMed] [Google Scholar]
  2. Feinblatt B. I., Aceto T., Jr, Beckhorn G., Bruck E. Percutaneous absorption of hydrocortisone in children. Am J Dis Child. 1966 Sep;112(3):218–224. doi: 10.1001/archpedi.1966.02090120086008. [DOI] [PubMed] [Google Scholar]
  3. Feiwel M., James V. H., Barnett E. S. Effect of potent topical steroids on plasma-cortisol levels of infants and children with eczema. Lancet. 1969 Mar 8;1(7593):485–487. doi: 10.1016/s0140-6736(69)91588-8. [DOI] [PubMed] [Google Scholar]
  4. James V. H., Munro D. D., Feiwel M. Pituitary-adrenal function after occlusive topical therapy with betamethasone-17-valerate. Lancet. 1967 Nov 18;2(7525):1059–1061. doi: 10.1016/s0140-6736(67)90336-4. [DOI] [PubMed] [Google Scholar]
  5. Keczkes K., Frain-Bell W., Honeyman A. L., Sprunt G. The effect of adrenal function of treatment of eczema and psoriasis with triamcinolone acetonide. Br J Dermatol. 1967 Aug-Sep;79(8):475–486. doi: 10.1111/j.1365-2133.1967.tb11535.x. [DOI] [PubMed] [Google Scholar]
  6. Keipert J. A., Kelly R. Temporary Cushing's syndrome from percutaneous absorption of betamethasone 17-valerate. Med J Aust. 1971 Mar 6;1(10):542–544. doi: 10.5694/j.1326-5377.1971.tb87696.x. [DOI] [PubMed] [Google Scholar]
  7. Munro D. D., Clift D. C. Pituitary-adrenal function after prolonged use of topical corticosteroids. Br J Dermatol. 1973 Apr;88(4):381–385. doi: 10.1111/j.1365-2133.1973.tb07569.x. [DOI] [PubMed] [Google Scholar]
  8. SPENCER PEET J., DALY J. R., SMITH V. A SIMPLE METHOD FOR IMPROVING THE SPECIFICITY OF THE FLUORIMETRIC DETERMINATION OF ADRENAL CORTICOSTEROIDS IN HUMAN PLASMA. J Endocrinol. 1965 Feb;31:235–244. doi: 10.1677/joe.0.0310235. [DOI] [PubMed] [Google Scholar]
  9. Scoggins R. B., Kliman B. Percutaneous absorption of corticosteroids: systemic effects. N Engl J Med. 1965 Oct 14;273(16):831–840. doi: 10.1056/NEJM196510142731601. [DOI] [PubMed] [Google Scholar]
  10. Sparkes C. G., Wilson L. The clinical evaluation of a new topical corticosteroid, clobetasol propionate. An international controlled trial. Br J Dermatol. 1974 Feb;90(2):197–203. doi: 10.1111/j.1365-2133.1974.tb06385.x. [DOI] [PubMed] [Google Scholar]
  11. Staughton R. C., August P. J. Cushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate. Br Med J. 1975 May 24;2(5968):419–421. doi: 10.1136/bmj.2.5968.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WOOD J. B., FRANKLAND A. W., JAMES V. H., LANDON J. A RAPID TEST OF ADRENOCORTICAL FUNCTION. Lancet. 1965 Jan 30;1(7379):243–245. doi: 10.1016/s0140-6736(65)91526-6. [DOI] [PubMed] [Google Scholar]
  13. Walker S. R., Wilson L., Fry L., James V. H. The effect on plasma corticosteroid levels of the short term topical application of clobetasol propionate. Br J Dermatol. 1974 Sep;91(3):339–343. doi: 10.1111/j.1365-2133.1974.tb12904.x. [DOI] [PubMed] [Google Scholar]
  14. Woodbridge P. The use of a new topical steroid in general practice. Practitioner. 1974 May;212(1271):732–736. [PubMed] [Google Scholar]

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