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. 2006 Dec 1;2(12):e172. doi: 10.1371/journal.pcbi.0020172

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© 2006 Goryachev and Pokhilko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The activity (upper row) and the recovery time (bottom row) profiles of GTPase are plotted versus the total concentrations of GEF and GAP. Results shown in (A) and (C) were numerically simulated using the complete model, while those shown in (B) and (D) were calculated based on the analytical estimates derived from the reduced model. Note the good match between the simulated and analytically estimated results in a broad domain of parameter values.