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. Author manuscript; available in PMC: 2006 Dec 1.
Published in final edited form as: Drug Metab Dispos. 2006 Aug 25;34(12):2003–2010. doi: 10.1124/dmd.106.012005

Figure 3.

Figure 3

Transcriptional activation analysis of the Cyp2c37 5′-flanking region by mCAR. HepG2 cells were cotransfected with pRL-Tk (internal transfection control), expression vectors mCAR (pCR3) or empty (pCR3.1), and pGL3 Basic luciferase vectors containing varying lengths of the Cyp2c37 5′-flanking region to evaluate mCAR effects on gene reporter activity. Androstenol (10 μM) and TCPOBOP (250 nM) were used to modulate mCAR activity. These data represent the results of three independent transfections. P-values were determined using the Tukey-Kramer HSD Test. a p≤ 0.05, mCAR significantly increased luciferase activity compared to no receptor DMSO control group. b p ≤ 0.05, androstenol significantly decreased luciferase activity compared to mCAR DMSO treatment group.