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Alignment of CYP2C 5′-flanking regions and summary illustration of common mCAR and mPXR activators. A: Alignment of Cyp2c37 -2791 CAR-RE and surrounding sequence with corresponding 5′-flanking sequence of all presently known murine CYP2C genes. B: Ilustration showing the shared activators of the xenobiotic sensing nuclear receptors PXR and CAR and their respective genes that are induced.
