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. 2006 Sep 27;80(24):11946–11959. doi: 10.1128/JVI.01722-06

FIG. 6.

FIG. 6.

v-Cyclin mutant viruses do not induce splenomegaly by 16 days after intranasal infection. (A) Spleen weights of C57BL/6 mice 16 days after intranasal infection with 1,000 PFU of wild-type (WT) γHV68 (n = 8), v-cyc[STOP] (n = 15), v-cyc[STOPMR] (n = 15), v-cyc[K104E] (n = 10), v-cyc[K104MR] (n = 10), v-cyc[E133V] (n = 13), or v-cyc[E133MR] (n = 14). Statistically significant differences (P < 0.05), as determined by nonparametric Mann-Whitney analysis, are indicated. SPL, splenocytes. (B) Cell number in spleens of infected mice. Pooled samples of three to five spleens were analyzed for cell number per spleen following organ disruption and erythrocyte lysis. Data represent two to three independent experiments. Error bars represent the standard errors of the means.