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Circle formation by Ty1. (A) Ty1 circles may form by host homologous recombination (HR) and nonhomologous end joining (NHEJ) functions or by reverse transcription (RT). Ty1 elements may also undergo autointegration mediated by IN. (B) Characteristics of Ty1 circles formed by autointegration. TSD+, 5-bp target site duplication created upon IN-catalyzed integration.
