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. 2006 Oct 11;80(24):12312–12323. doi: 10.1128/JVI.01766-06

FIG. 1.

FIG. 1.

(A) Physical map of the HSV-1 genome showing the location of the UL27, UL28, and UL29 genes. UL and US refer to the long and short unique region sequences. On the next line, the BamHI region located between nucleotides 52588 and 60362 of the HSV-1 genome are expanded. The locations of the UL27, UL28, and UL29 genes are indicated, with the boxed regions representing the open reading frames for these genes. (B) Insertion mutations within the HSV-1 UL28 gene. Numbers above the line indicate the location (amino acid number of UL28 open reading frame) where 12 or 24 bp was added to the UL28 gene, resulting in the addition of four or eight amino acids. Numbers below the line indicate the location where a nonsense linker was added to the UL28 gene. Filled circles indicate mutants which grow on only UL28-complementing cells; white circles indicate mutants which grow on noncomplementing Vero cells. At the bottom, the locations of the insertions and the predicted amino acid changes are shown. The number denotes the last unchanged amino acid before the insertions.