Table 1. Functional classification of L.major chromosome 3 genes.
| Category | n | |
|---|---|---|
| Cell growth, division and DNA synthesis | 5 | |
| Putative DNA primase large subunit dp58 (Chr3_0070) | ||
| Helicase 1 (Chr3_0490) | ||
| Helicase 2 (Chr3_0610) | ||
| Serine-threonine protein kinase 4 (Chr3_0170) | ||
| RNA-binding protein (Chr3_0430) | ||
| Cell rescue, defense, death and aging | 0 | |
| Cellular organization/biogenesis | 1 | |
| Ankyrin repeat protein 1 (Chr3_0390) | ||
| Energy generation | 1 | |
| Quinone oxidoreductase (Chr3_0480) | ||
| Intracellular trafficking | 0 | |
| Metabolism | 6 | |
| Long chain fatty acyl CoA synthetase (Chr3_0180) | ||
| 2-Aminoethylphosphonate:pyruvate aminotransferase (Chr3_0030) | ||
| Inorganic pyrophosphatase (Chr3_0820) | ||
| δ-1-Pyroline-5-carboxylate dehydrogenase (Chr3_0160) | ||
| d-3-Phosphoglycerate dehydrogenase (Chr3_0020) | ||
| Multicopper oxidase 1 (Chr3_0860) | ||
| Protein destination | 3 | |
| 26S Protease regulatory ATPase subunit (Chr3_0450) | ||
| Protein arginine methyltransferase (Chr3_0500) | ||
| Cytochrome c oxidase assembly protein (Chr3_0080) | ||
| Protein synthesis | 4 | |
| Elongation initiation factor 2, α subunit (Chr3_0890) | ||
| Ribosomal protein L38 (Chr3_0200) | ||
| 60S Acidic ribosomal protein P1_2 (Chr3_0350) | ||
| 60S Acidic ribosomal protein P1_1 (Chr3_0345) | ||
| Signal transduction | 2 | |
| Serine-threonine protein kinase 2 (Chr3_0280) | ||
| Serine-threonine protein kinase 3 (Chr3_0690) | ||
| Structural RNA | 1 | |
| tRNALysCUU (Chr3_tRNA_Lys01) | ||
| Transcription and RNA processing | 1 | |
| U2AF23/25 spliceosome component (Chr3_0155) | ||
| Transport | 6 | |
| Lysine-arginine-ornithine transport system kinase 1 (Chr3_0510) | ||
| Leishmania unknown permease 1 (Chr3_0330) | ||
| Phosphate-repressible phosphate permease 1 (Chr3_0410) | ||
| ABC transporter protein 1 (Chr3_0130) | ||
| Choline transporter protein 1 (Chr3_0060) | ||
| Tubulin-specific chaperone (Chr3_0680) | ||
| Unclassified | 65 | |
| No homology/motifs | 14 | |
| Chr3_0115; Chr3_0140; Chr3_0150; Chr3_0205; Chr3_0220; Chr3_0290; Chr3_0360; Chr3_0370; Chr3_0470; Chr3_0640; Chr3_0650; Chr3_0720; Chr3_0770; Chr3_0850. | ||
| Uninformative blast homology/motifs | 32 | |
| Chr3_0010; Chr3_0015; Chr3_0040; Chr3_0100; Chr3_0110; Chr3_0210; Chr3_0230; Chr3_0240; Chr3_0270; Chr3_0300; Chr3_0310; Chr3_0312; Chr3_0315; Chr3_0340; Chr3_0400; Chr3_0420; Chr3_0460; Chr3_0510; Chr3_0590; Chr3_0600; Chr3_0630; Chr3_0670; Chr3_0700; Chr3_0710; Chr3_0730; Chr3_0760; Chr3_0780; Chr3_0790; Chr3_0800; Chr3_0830; Chr3_0840; Chr3_0880. | ||
| Shared with other Kinetoplastidae | 20 | |
| Chr3_0050; Chr3_0090; Chr3_0120; Chr3_0175; Chr3_0180; Chr3_0250; Chr3_0260; Chr3_0380; Chr3_0440; Chr3_0485; Chr3_0520; Chr3_0540; Chr3_0550; Chr3_0560; Chr3_0580; Chr3_0620; Chr3_0660; Chr3_0740; Chr3_0750; Chr3_0870. | ||
| Total for chromosome 3 | 96a |
aIncluding the structural RNA Chr3_tRNA_Lys01