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. 1993 Dec 11;307(6918):1519–1524. doi: 10.1136/bmj.307.6918.1519

Early growth and death from cardiovascular disease in women.

C Osmond 1, D J Barker 1, P D Winter 1, C H Fall 1, S J Simmonds 1
PMCID: PMC1679586  PMID: 8274920

Abstract

OBJECTIVE--To determine whether the link suggested between growth in utero and during infancy and death from cardiovascular disease in men is also present in women. DESIGN--Follow up study of women and men whose birth weight and weight at 1 year of age had been recorded. SETTING--Hertfordshire, England. SUBJECTS--5585 women and 10,141 men born during 1911-30. MAIN OUTCOME MEASURES--Standardised mortality ratios for cardiovascular disease. RESULTS--Among women and men death rates from cardiovascular disease fell progressively between the low and high birth weights groups (chi 2 = 4.3, p = 0.04 for women, chi 2 = 8.5, p < 0.005 for men). Cardiovascular deaths in men but not women were also strongly related to weight at 1 year, falling progressively between the low and high weight groups (chi 2 = 27.5, p < 0.0001). The highest cardiovascular death rates in women were among those with below average birth weight but above average weight at 1 year. In men the highest rates were among those with below average birth weight and below average weight at 1 year. CONCLUSION--Relations between cardiovascular disease and birth weight are similar in men and women. In men cardiovascular disease is also related to weight gain in infancy.

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Selected References

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  1. Barker D. J., Gluckman P. D., Godfrey K. M., Harding J. E., Owens J. A., Robinson J. S. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993 Apr 10;341(8850):938–941. doi: 10.1016/0140-6736(93)91224-a. [DOI] [PubMed] [Google Scholar]
  2. Barker D. J., Hales C. N., Fall C. H., Osmond C., Phipps K., Clark P. M. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993 Jan;36(1):62–67. doi: 10.1007/BF00399095. [DOI] [PubMed] [Google Scholar]
  3. Barker D. J., Martyn C. N., Osmond C., Hales C. N., Fall C. H. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993 Dec 11;307(6918):1524–1527. doi: 10.1136/bmj.307.6918.1524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barker D. J., Meade T. W., Fall C. H., Lee A., Osmond C., Phipps K., Stirling Y. Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ. 1992 Jan 18;304(6820):148–152. doi: 10.1136/bmj.304.6820.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barker D. J., Osmond C., Simmonds S. J., Wield G. A. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ. 1993 Feb 13;306(6875):422–426. doi: 10.1136/bmj.306.6875.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Barker D. J., Winter P. D., Osmond C., Margetts B., Simmonds S. J. Weight in infancy and death from ischaemic heart disease. Lancet. 1989 Sep 9;2(8663):577–580. doi: 10.1016/s0140-6736(89)90710-1. [DOI] [PubMed] [Google Scholar]
  7. Berry G. The analysis of mortality by the subject-years method. Biometrics. 1983 Mar;39(1):173–184. [PubMed] [Google Scholar]
  8. Burgoyne P. S. A Y-chromosomal effect on blastocyst cell number in mice. Development. 1993 Jan;117(1):341–345. doi: 10.1242/dev.117.1.341. [DOI] [PubMed] [Google Scholar]
  9. Edwards C. R., Benediktsson R., Lindsay R. S., Seckl J. R. Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet. 1993 Feb 6;341(8841):355–357. doi: 10.1016/0140-6736(93)90148-a. [DOI] [PubMed] [Google Scholar]
  10. Fall C. H., Barker D. J., Osmond C., Winter P. D., Clark P. M., Hales C. N. Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. BMJ. 1992 Mar 28;304(6830):801–805. doi: 10.1136/bmj.304.6830.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fowden A. L. The role of insulin in prenatal growth. J Dev Physiol. 1989 Oct;12(4):173–182. [PubMed] [Google Scholar]
  12. Gluckman P. D., Gunn A. J., Wray A., Cutfield W. S., Chatelain P. G., Guilbaud O., Ambler G. R., Wilton P., Albertsson-Wikland K. Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. The International Board of the Kabi Pharmacia International Growth Study. J Pediatr. 1992 Dec;121(6):920–923. doi: 10.1016/s0022-3476(05)80342-7. [DOI] [PubMed] [Google Scholar]
  13. Hales C. N., Barker D. J., Clark P. M., Cox L. J., Fall C., Osmond C., Winter P. D. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991 Oct 26;303(6809):1019–1022. doi: 10.1136/bmj.303.6809.1019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Harding J., Liu L., Evans P., Oliver M., Gluckman P. Intrauterine feeding of the growth retarded fetus: can we help? Early Hum Dev. 1992 Jun-Jul;29(1-3):193–197. doi: 10.1016/0378-3782(92)90149-b. [DOI] [PubMed] [Google Scholar]
  15. Holmes G. E., Miller H. C., Hassanein K., Lansky S. B., Goggin J. E. Postnatal somatic growth in infants with atypical fetal growth patterns. Am J Dis Child. 1977 Oct;131(10):1078–1083. doi: 10.1001/archpedi.1977.02120230024003. [DOI] [PubMed] [Google Scholar]
  16. Law C. M., de Swiet M., Osmond C., Fayers P. M., Barker D. J., Cruddas A. M., Fall C. H. Initiation of hypertension in utero and its amplification throughout life. BMJ. 1993 Jan 2;306(6869):24–27. doi: 10.1136/bmj.306.6869.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Martyn C. N., Barker D. J., Osmond C. Selective migration by birthweight. J Epidemiol Community Health. 1993 Feb;47(1):76–76. doi: 10.1136/jech.47.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pedersen J. F. Ultrasound evidence of sexual difference in fetal size in first trimester. Br Med J. 1980 Nov 8;281(6250):1253–1253. doi: 10.1136/bmj.281.6250.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Persson E., Jansson T. Low birth weight is associated with elevated adult blood pressure in the chronically catheterized guinea-pig. Acta Physiol Scand. 1992 Jun;145(2):195–196. doi: 10.1111/j.1748-1716.1992.tb09356.x. [DOI] [PubMed] [Google Scholar]
  20. Phillips D. I., Barker D. J., Osmond C. Infant feeding, fetal growth and adult thyroid function. Acta Endocrinol (Copenh) 1993 Aug;129(2):134–138. doi: 10.1530/acta.0.1290134. [DOI] [PubMed] [Google Scholar]
  21. Phipps K., Barker D. J., Hales C. N., Fall C. H., Osmond C., Clark P. M. Fetal growth and impaired glucose tolerance in men and women. Diabetologia. 1993 Mar;36(3):225–228. doi: 10.1007/BF00399954. [DOI] [PubMed] [Google Scholar]
  22. Robinson S., Walton R. J., Clark P. M., Barker D. J., Hales C. N., Osmond C. The relation of fetal growth to plasma glucose in young men. Diabetologia. 1992 May;35(5):444–446. doi: 10.1007/BF02342441. [DOI] [PubMed] [Google Scholar]
  23. Seidman D. S., Laor A., Gale R., Stevenson D. K., Mashiach S., Danon Y. L. Birth weight, current body weight, and blood pressure in late adolescence. BMJ. 1991 May 25;302(6787):1235–1237. doi: 10.1136/bmj.302.6787.1235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Villar J., Smeriglio V., Martorell R., Brown C. H., Klein R. E. Heterogeneous growth and mental development of intrauterine growth-retarded infants during the first 3 years of life. Pediatrics. 1984 Nov;74(5):783–791. [PubMed] [Google Scholar]
  25. WIDDOWSON E. M., MCCANCE R. A. THE EFFECT OF FINITE PERIODS OF UNDERNUTRITION AT DIFFERENT AGES ON THE COMPOSITION AND SUBSEQUENT DEVELOPMENT OF THE RAT. Proc R Soc Lond B Biol Sci. 1963 Oct 22;158:329–342. doi: 10.1098/rspb.1963.0051. [DOI] [PubMed] [Google Scholar]
  26. Williams S., St George I. M., Silva P. A. Intrauterine growth retardation and blood pressure at age seven and eighteen. J Clin Epidemiol. 1992 Nov;45(11):1257–1263. doi: 10.1016/0895-4356(92)90167-l. [DOI] [PubMed] [Google Scholar]

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