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(A–D) Four hours after initiation of sepsis-induced ALI by LPS and zymosan, mice displayed reduced gas exchange (A), increased accumulation of neutrophils in the intravascular (B) and alveolar (C) compartments, and permeability (D). Platelet depletion by Ab prior to the induction of the sepsis model caused improved gas exchange, reduced permeability (D), and neutrophil accumulation in the intravascular (B) and alveolar (C) spaces. #P < 0.05.
