Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of Tyk2 regulation in the IFNα receptor-kinase complex. Tyk2 is associated with IFNAR1 through its N region. The KL domain maintains the TK domain in an unphosphorylated and resting conformation. Severe disruption of KL leads to hyperphosphorylation of the protein. Upon IFNα binding, KL-dependent conformational changes allow transition of the receptor-kinase complex to a high-affinity binding state where Tyk2 and JAK1 are stabilized in their activated conformations.
