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Sensitivity to IFN of 11,1 cells stably reconstituted with Tyk2 point mutants
| Cell line | IFN conc. for 50% cell death, IU/ml
|
|
|---|---|---|
| IFNα2 | IFNβ | |
| 11,1 | >10,000 | 400 |
| WT | <10 | <40 |
| V584D | 1,000 | 40 |
| G596V | 1,000 | 40 |
| H669P | >10,000 | 400 |
| R856G | >10,000 | 400 |
Transcriptional response to IFNs was measured by using the 6TG cytotoxicity assay.
