IS element and defective phage differences. Locus names and genome locations on the left side are based on the MG1655 genome. IS1A, IS1B, IS1C, etc. are named alphabetically to distinguish individual insertions (Supplementary Figure 1). IS elements, black arrows; sites, red arrowheads; six ISs disrupt orfs, red bars (alsK, dcuA, gatA, rcsC, tdcD, and tnaB); and phage genes, green arrows.