Table 1.

Summary of E. coli K-12 MG1655 genome corrections^a

Change	Locationb	No. sitesc
1-nt substitution	Intergenic	12
	Coding	56
2-nt substitution	Intergenic	5
	Coding	26
Multiple nt substitution	Intergenic	2
	Codingd	2
	RNA	1
1-nt indel	Intergenic	48 (27)
	Coding	75 (50)
	RNA	1 (0)
2-nt indel	Intergenic	6 (5)
	Coding	3 (2)
3-nt indele	Coding	4 (3)
4-nt indel	Coding	1 (1)
6-nt indelf	Coding	1 (1)
	Total	243 (193)

^aThe actual sequence corrections are in Supplementary Table 2.

^bMost genes affected have only single corrections. Exceptions had five (yfjP, alx, ppiC), six (yhdZ), seven (yieP, yjgN), 11 (yigL), and 14 (yibJ) corrections.

^cTotals are given with the number of insertions in parentheses. Indels changed not only the length of particular gene products but also the number of gene products, for example, corrections resulting in gene fusion event(s), or conversion from one to two genes.

^dOne multiple nt substitution changes coding of ebgA (CAAG to AGCA at nt 3 222 944); the other results in a frameshift in gntT due to a 2-nt addition (C to GCG at nt 3 544 358).

^eA 1-codon deletion lies in yghG and 1-codon insertions lie in rffE, yiaY, and yieP.

^fA 2-codon insertion lies in arcB.