Figure 1.

DZF domains from various transcription factors. The top of the figure presents a schematic of a DZF domain with amino- (N) and carboxy- (C) terminal fingers represented as ovals and the interfinger linker as a connecting bar. The bottom portion of the figure shows an amino-acid sequence alignment of DZFs from human Ikaros, human Helios, human Aiolos, human Eos, human Pegasus, human TRPS-1, Drosophila melanogaster (D.m.) Hunchback, Locusta migratoria (L.m.) Hunchback, Helobdella triserialis (H.t.) Hunchback, and Caenorhabditis elegans (C.e.) Hunchback. Conserved cysteines and histidines are highlighted in blue. Positions showing 80% or greater conservation among the 10 DZF domains shown are highlighted in yellow.