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Transcriptional master regulators profiled in primary human hepatocytes
| Regulator | Function | PFAM category | Genes bound |
|---|---|---|---|
| HNF1α | Metabolic control | POU homeodomain | 1016 |
| HNF4α | Development, metabolism | Nuclear receptor | 4519 |
| HNF6 (ONECUT1) | Development | CUT homeodomain | 1306 |
| HNF3β (FOXA2) | Development | Forkhead | 890 |
| CREB1 | cAMP response | bZIP | 2197 |
| USF1 | Glucose, lipid metabolism | Basic helix–loop–helix | 1632 |
