Table 2.

Thermodynamics of the CD4-gp120 interaction at 37°C by isothermal titration calorimetry

	ΔG°, kcal/mol	ΔH°, kcal/mol	−TΔS°, kcal/mol	ΔC°, kcal/mol/K	KD, nM
WD61 full-length gp120	−11.8  ± 0.3	−63  ± 3	51.2  ± 3	−1.2  ± 0.2	5  ± 3
Core gp120	−9.5  ± 0.1	−62  ± 3	52.5  ± 3	−1.8  ± 0.4	190  ± 30