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. 2006 May 16;2:2006.0028. doi: 10.1038/msb4100073

Figure 4.

Figure 4

Types of modules. (A) Transcriptional cascade modules exhibiting ultrasensitive behavior. Ultrasensitivity increases as a function of cascade depth (reprinted from Hooshangi et al (2005); copyright 2005, NAS). (B) Schematics of mutant variants of the diverter scaffold. Only the appropriate connectivity (first column) activates HOG1 and allows cell growth (bottom row of micrographs). Growth indicates α-factor-dependent osmoresistance and therefore correct diverter function (Figure 4B reprinted (excerpted) with permission from, Figure 4, Park SH et al, Science 299: 1061. Copyright 2003 AAAS). (C) The metabolator uses enzymatic reactions that generate acetyl phosphate (AcP) from acetate (HOAc) to elicit oscillations in reporter gene fluorescence under control of the tac promoter (Ptac). Graphs depict oscillations in reporter gene fluorescence over time (Figure 4C reprinted (excerpted) with permission from Fung E et al, Nature 435: 118–122. Copyright 2005 NPG).