Figure 4.

NET analysis of the E. coli metabolome data (Schaub et al, 2006). Abbreviations: pgi, glucose 6-phosphate isomerase; pfk, phosphofructose kinase; pyk, pyruvate kinase; g6pdh, glucose 6-phosphate dehydrogenase; pgl, phosphogluconolactonase; gnd, phosphogluconate dehydrogenase; rpe, ribulosephosphate epimerase; tkt1, transketolase; tkt2, transketolase; tala, transaldolase; edd, phosphogluconate dehydratase; eda, phosphogluconate aldolase; acont, acontinase; icdh, isocitrate de-hydrogenase; succoas, succinyl-CoA synthase; sucdh, succinate dehydrogenase; fum, fumerase; icl, isocitrate lyase; mals, malate synthase; ppc, phosphoenolpyruvate carboxylase; ppck, phosphoenolpyruvate carboxykinase; pgmt, phosphoglucomutase; g3pd, glycerol 3-phosphate dehydrogenase; pgcd, phosphoglycerate dehydrogenase; sulr, sulfite reductase; G6P, glucose 6-phosphate; F6P, fructose 6-phosphate; F16P, fructose 1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; G3P, glyceraldehyde 3-phosphate; 13DPG, 1,3-diphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; 6PGL, 6-phosphogluconolactone; 6PGC, 6-phosphogluconate; RU5P, ribulose 5-phosphate; R5P, ribose 5-phosphate; X5P, xylulose 5-phosphate; S7P, seduheptulose 7-phosphate; E4P, erythrose 4-phosphate; 2DDG6P, dehydrodeoxy-6-phosphogluconate; ACCOA, acetyl-CoA; CIT, citrate; ICIT, isocitrate; AKG, α-ketogluterate; SUCCOA, succinyl-CoA; SUCC, succinate; FUM, fumerate; MAL, malate; OXA, oxaloacetate; G1P, glucose 1-phosphate; GLYC3P, glycerol 3-phosphate; 3PHP, 3-phosphohydroxypyruvate; SO₃²⁻, sulfide; H₂S, hydrogen sulfide. (Summation of the inferred concentration ranges of the pooled metabolites (e.g. 2PG and 3PG) can exceed the actually measured (pooled) concentration of these metabolites. The reason for this is the introduced uncertainty in the measured concentrations of these pooled metabolites (in order to account for potential measurement uncertainties).)