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Requirement for p21 and p27 in G1 arrest by ER-blocking drugs or estradiol-depletion. MCF-7 cells were arrested by estradiol depletion or by treatment with 4-OH TAM or ICI 182780. The graph indicates the percentage of S phase cells after a 21-h exposure to lipid only (black bars), antisense (white bars), or mismatch (hatched bars) oligonucleotides to either p21 or p27.
